Triphenylphosphine → HCID 69117450, compound

Participants

Reaction Steps

Treatment of (2R)-2-(azidomethyl)-8-(4-chloro-2-methylphenyl)-7-fluorochroman (0.30 g, 0.90 mmol) with polymer-bound triphenylphosphine (3 mmol/g, 0.5 g, 1.50 mmol) in THF (10 mL) and water (0.5 mL) according to the procedure described for Example 69, Step 10 provided 0.21 g (69%) of ((2R)-8-(4-chloro-2-methylphenyl)-7-fluorochroman-2-yl)methanamine hydrochloride as a white solid salt, mp 100–102° C.; MS (ESI) m/z 306.1 ([M+H]+).

Provenance & Evidence