HCID 86609150, compound → HCID 86609149, compound

Participants

Reaction Steps

Treatment of (2R)-2-(2′,4′-dichloro-6-fluoro-3-(prop-1-enyl)biphenyl-2-yloxy)but-3-enyl 4-methylbenzenesulfonate (0.6 g, 1.15 mmol) with benzylidene-bis(tricyclohexylphosphine)dichlororuthenium (0.30 g, 0.36 mmol) in 1,2-dichloroethane (30 mL) according to the procedure described for Example 69, Step 7 provided 0.35 g (63%) of ((2R)-8-(2,4-dichlorophenyl)-7-fluoro-2H-chromen-2-yl)methyl 4-methylbenzenesulfonate as a brown oil.

Provenance & Evidence