Triphenylphosphine → HCID 69116749, compound

Participants

Reaction Steps

Treatment of (2R)-2-(azidomethyl)-8-(2,4-dichlorophenyl)-7-fluorochroman (0.22 g, 0.62 mmol) with polymer-bound triphenylphosphine (3 mmol/g, 0.35 g, 1.05 mmol) in THF (10 mL) and water (0.5 mL) according to the procedure described for Example 69, Step 10 provided 97 mg (43%) of ((2R)-8-(2,4-dichlorophenyl)-7-fluorochroman-2-yl)methanamine hydrochloride as a white solid salt, mp 164–166° C.; MS (ESI) m/z 326.0 ([M+H]+); [α]D25=−26.00° (c=1% SOLN, MeOH).

Provenance & Evidence