Boron tribromide → HCID 69117604, compound

Participants

Reaction Steps

To a solution of 5-fluoro-2-methoxy-2′-phenylbiphenyl (7.3 g, 26.2 mmol) in methylene chloride (100 mL) cooled to −78° C. was added through syringe boron tribromide (1.0 M in dichloromethane, 40.0 mL, 40.0 mmol). The reaction mixture was stirred and allowed to warm up to room temperature overnight. The resulting mixture was diluted with dichloromethane, washed with water and saturated sodium chloride, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by ISCO using a solvent gradient of 0 to 40% ethyl acetate in hexanes provided 6.8 g (98%) of 5-fluoro-2′-phenylbiphenyl-2-ol as a light brown oil.

Provenance & Evidence