Trifluoroacetic acid → Valienamine

Participants

Reaction Steps

1 g of a pure acarbose derivative (monosaccharide and trisaccharide) were place into 10% TFA solution at 5% final concentration. While putting pressure using an autoclave, at reaction temperature of 121° C., it was reacted for 30 minutes to 1 hour, followed by removal of TFA and water. Then, by using ion-exchange resins for purification, 0.46 g and 0.30 g of valienamine were obtained, respectively.

Provenance & Evidence