7-Benzyl-4-hydroxy-3-methyl-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester → 7-Benzyl-4-chloro-6,7-dihydro-3-methyl-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

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This compound was prepared from 7-benzyl-4-hydroxy-3-methyl-6-oxo-6,7-dihydro-thieno[2,3-b]pyrdine-5-carboxylic acid ethyl ester (61) by applying a similar procedure as described for the preparation of 7-benzyl-4-chloro-6,7-dihydro-6-oxo-thieno[2,3-b]pyrdine-5-carbonitrile (64). Yield 87%. 1H-NMR (DMSO-d6): δ 2.48 (s, 3H), 5.36 (s, 2H), 7.14 (s, 1H), 7.32 (m, 5H) ppm; EIMS m/z 315 (M+1).

Provenance & Evidence