HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole-3-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole-3-carboxylic acid methyl ester | HCID 59702320 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole-3-carboxylic acid methylamide | HCID 59702363 | 88% |
Reaction Steps
A solution of 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole-3-carboxylic acid methyl ester (35b; 0.050 g, 0.15 mmol) in 4 mL of a 2 M solution of methylamine in methanol was stirred for 6 d, then concentrated to a white solid. Column chromatography (0→45% EtOAc/hexanes) afforded of 7-(2,4-dichloro-phenyl)-2-methyl-2H-indazole-3-carboxylic acid methylamide (35d; 0.044 g; 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365211B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-75e21a4f96674bf3835b0e952b77747d |
| Source note | uspto-grants-2008_04 |