反应详情

In an amount of 37.8 mg of 6-cyanoquinoline (Justus Liebigs Ann. Chem., 1966, 699, 98-106) was dissolved in 1 ml of carbon tetrachloride, added with 13 μl of bromine, and then stirred under reflux. After 2 hours, the reaction mixture was added with 20 μl of pyridine, and further stirred for 23 hours under reflux. The reaction mixture was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate (4:1)) to obtain 34.8 mg of the title compound.

1. temperatureunder reflux
2. stirringfurther stirred for 23 hours
3. temperatureunder reflux
4. concentrationThe reaction mixture was concentrated under reduced pressure
5. customthe resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate (4:1))