Trifluoroacetic acid → HCID 178478966, compound

Participants

Reaction Steps

To a stirring solution of (2-chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-{3-[3-(ethoxymethyl-1,2,4-triazol-3-ylmethyl)-phenoxy]-propyl)amine (mixture of regioisomers, 90 mg, 0.135 mmol) in dichloromethane (1.5 mL) was added triethylsilane (157 mg, 1.35 mmol). The reaction mixture was treated with TFA (0.5 mL) and then stirred overnight Solvent was removed and the residue was purified by preparative HPLC (YMC CombiPrep PDS, 75×30 mm, 25 mL/min, A: acetonitrile B: water, A: 60 to 100% during 10 min, UV detection at 254 nm) to give an oil. The oil was dissolved in diethyl ether and acidified with 1.0 M HCl/diethyl ether to give 40 mg (48% yield) of the title compound as a yellow oil. MS (ESI) 605.0 (M+).

Provenance & Evidence