HCID 69251257, compound → HCID 59701475, compound

Participants

Reaction Steps

(2-Chloro-3-trifluoromethyl-benzyl)-(2,2-diphenyl-ethyl)-[3-(4-chloro-3-nitro-phenoxy)-propyl]-amine (400 mg, 0.66 mmol) was hydrogenated over 10% Pd/C (40 mg) at 60 psi at room temperature in the presence of 1N HCl-Et2O (10 ml). After 24 h, the reaction mixture was filtered and concentrated in vacuo to give a heavy oil. HPLC purification of the crude amine (Phenomonex Luna Combi HTS, 5 micron C18, 275 mm×30 mm, 10% CH3CN— water gradient to 95% CH3CN) afforded the title compound as an oil. Treatment of the free base with 1N HCl-Et2O (excess), followed by filtration and isolation of the resulting precipitate gave the title compound as a brown solid, 18.5 mg (4.3%). MS (ESI) 572.5 (M+).

Provenance & Evidence