反应详情

温度

40 °C

To a stirring suspension of piperidin-4-yl-acetic acid hydrochloride in MeOH (15 mL) at −5° C. was added thionyl chloride (1.12 mL, 15.3 mmol) dropwise. The reaction mixture was allowed to reach to RT then heated to 40° C. for 4 h. The reaction mixture was concentrated in vacuo and the resulting white solid was azeotroped with toluene twice. Washed with ether and filtered to give 2.7 g (quantitative yield). MS(ESI) 158.2 (M+H+).

1. customto reach to RT
2. concentrationThe reaction mixture was concentrated in vacuo
3. customthe resulting white solid was azeotroped with toluene twice
4. washWashed with ether
5. filtrationfiltered
6. customto give 2.7 g (quantitative yield)