Morpholine → HCID 178516081, compound

HRID 902647Notes

Reaction equation

Cl[C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[N:9]1([C:2]2[N:7]=[C:6]([OH:8])[CH:5]=[CH:4][CH:3]=2)[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

Reactant 2

HCID 8083Morpholine

HCID 1785160256-chloropyridin-2-ol

Product 1

HCID 178516081HCID 178516081, compound

Conditions

Temperature: 90 °C

Procedure

To a stirring solution of morpholine (10 ml) was added 6-chloro-2-pyridinol (1.5 g, 11.57 mmol) and the mixture was heated at 90° C. for 60 h. The reaction mixture was cooled to RT and concentrated under reduced pressure (while heating) to afford the title compound as a brown solid (85%. The crude material was used without further purification. MS (ESI) 181.2 (M+H+).

Workup

temperatureThe reaction mixture was cooled to RT
concentrationconcentrated under reduced pressure (while heating)

Sources & evidence

ORD record: ord-e7334acbdcd646aa9d5bef313afa491f
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365085B2

Reaction notes

Loading…