Water → HCID 59701420, compound

Participants

Reaction Steps

A solution of 2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl]((S)-2-phenyl-propyl)amino]-(R)-1-methyl-propoxy}phenyl)acetic acid methyl ester (20 mg, 0.036 mmol) in THF (1 ml) at 0° C., was treated with LiAlH4 (100 uL of a 1N solution in THF), and the reaction was stirred at 0° for 45 minutes. Ethyl acetate (1 ml) was added, the reaction warmed to RT, and water (2 ml) was added. The mixture was extracted with ethyl acetate. The organic extracts were dried and the solvent removed. The residue was chromatographed over silica gel (hexane/Ethyl acetate:3/7) to give the title compound as a pure oil (15 mg, 91%). MS (ESI) 520.0 (M+H)+.

Provenance & Evidence