HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → tert-butyl N-((3-hydroxyphenyl)methyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | 3-(Aminomethyl)phenol | HCID 735894 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-butyl N-((3-hydroxyphenyl)methyl)carbamate | HCID 18369568 | 22.1% |
Reaction Steps
3-hydroxybenzylamine (Apin, 1.0 g, 8.1 mmole) was dissolved in DMF(25 ml). Triethylamine (0.33 ml, 2.4 mmole) and (BOC)2O (1.8 g, 8.1 mmole) were added, the mixture stirred over night at room temperature under argon atmosphere. The reaction was concentrated, chromatographed on silica gel (0 to 20% EtOAc/hexanes) to give the titled compound (400 mg, 22%). MH+223.0
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365085B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-76fd4b733a574e44b86d724bf907e2dc |
| Source note | uspto-grants-2008_04 |