O-Cresol → HCID 10152807, compound

Participants

Reaction Steps

To a solution of 3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propan-1-ol (0.065 g, 0.145 mmol) in toluene (4 ml) at ambient temperature was added o-cresol (0.020 g, 0.186 mmol) under Argon with stirring. The mixture was treated with polymer bound PPh3 (0.076 g, 0.228 mmol). After 15 minutes of stirring, the mixture was treated with DIAD (0.036 g, 0.178 mmol) and was stirred at ambient temperature overnight. The reaction mixture was filtered then concentrated, in vacuo, to dryness. The oil was dissolved in DMSO and was purified via reverse-phase HPLC to yield the title compound (0.033 g, 42%); MS (ES+) m/e 539 [M+H]+.

Provenance & Evidence