Methylamine → HCID 59701456, compound

Participants

Reaction Steps

A solution of 4-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-benzaldehyde, (0.0443 g, 0.080 mmol) in dichloromethane (1 ml) and AcOH (00.1 mL), was treated with CH3NH2 (40% solution in H2O, 0.073 mmol) at ambient temperature. To the mixture was added NaBH(OAc)3 (0.017 g, 0.080 mmol), and the reaction was stirred overnight. The reaction mixture was then concentrated, in vacuo, to an oil, which was then dissolved in DMSO and purified via reverse-phase HPLC to afford the title compound (0.007 g, 15%); MS (ES+) m/e 568 [M+H]+.

Provenance & Evidence