Methyl bromoacetate → HCID 69253830, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amine (81 mg, 0.15 mmol) in methanol (15 ml) was treated with bromo-acetic acid methyl ester (46 mg, 0.30 mmol) diisopropylethylamine (46 mg, 0.36 mmol). The resulting solution was heated at 50° C. for 4 hours, cooled down and concentrated. The crude material was dissolved in EtOAc and washed with brine (1×), dried over sodium sulfate, and filtered. The filtrate was concentrated to afford title compound as an oil (70 mg, 76%). MS(ES) m/e 625.2 (M+).

Provenance & Evidence