(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}phenylamino)-acetic acid methyl ester → HCID 69254783, compound

HRID 902710Notes

Reaction equation

HRID 902710 reaction equation
C[O:2][C:3](=[O:44])[CH2:4][N:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:14][CH2:15][CH2:16][N:17]([CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([C:39]([F:42])([F:41])[F:40])[C:34]=2[Cl:43])[CH2:18][CH:19]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:8]=1)[CH3:6].COC(=O)CNC1C=CC=C(OCCCN(CC2C=CC=C(C(F)(F)F)C=2Cl)CC(C2C=CC=CC=2)C2C=CC=CC=2)C=1>>[ClH:43].[Cl:43][C:34]1[C:35]([C:39]([F:40])([F:41])[F:42])=[CH:36][CH:37]=[CH:38][C:33]=1[CH2:32][N:17]([CH2:18][CH:19]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)[C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH2:16][CH2:15][CH2:14][O:13][C:9]1[CH:8]=[C:7]([N:5]([CH2:4][C:3]([OH:44])=[O:2])[CH3:6])[CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 69253762(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}phenylamino)-acetic acid methyl esterHCID 69253830HCID 69253830, compound

Product 1

HCID 69254783HCID 69254783, compound

Procedure

Following the procedure of Example 178 step (c) except [(3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-N-methyl-amino]-acetic acid methyl ester was used in step (c) instead of (3-{3-[(2-chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}phenylamino)-acetic acid methyl ester the title compound was obtained as a solid, 65 mg (96%). MS (ES) m/e 611.2 (M+).

Sources & evidence

ORD record
ord-927a1ab3cc94463db0a08cce3804691e
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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