3-Chlorophenylacetic acid → 2-(3-Chlorophenyl)propanoic acid

HRID 902726Notes

Reaction equation

HRID 902726 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.Cl[C:13]1C=CC=CC=1C(C)C(O)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:13])[C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 158793-Chlorophenylacetic acidHCID 126365742-(2-Chlorophenyl)propanoic acid

Product 1

HCID 131095352-(3-Chlorophenyl)propanoic acidYield 57%

Procedure

The titled compound was prepared from m-chlorophenylacetic acid in 57% yield in the same manner as the preparation of 2-(2-Chlorophenyl)propionic acid in Example 184a. MS (ESI) 185 (MH+).

Sources & evidence

ORD record
ord-b43ac1d45f5848ca9ddbfdcdfcc9a12e
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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