N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine → n-(2-[3-Chlorophenyl]-propyl)-n(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine

HRID 902728Notes

Reaction equation

HRID 902728 reaction equation
[Cl:1]C1C(C(F)(F)F)=CC=CC=1CNCC(C1C=CC=CC=1Cl)C.Cl[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[CH:31]([CH3:61])[CH2:32][N:33]([CH2:46][CH2:47][CH2:48][O:49][C:50]1[CH2:51][C:52](=[CH:56][C:57]([O:59][CH3:60])=[O:58])[CH:53]=[CH:54][CH:55]=1)[CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[C:36]=1[Cl:45]>>[Cl:1][C:30]1[CH:25]=[C:26]([CH:31]([CH3:61])[CH2:32][N:33]([CH2:46][CH2:47][CH2:48][O:49][C:50]2[CH2:51][C:52](=[CH:56][C:57]([O:59][CH3:60])=[O:58])[CH:53]=[CH:54][CH:55]=2)[CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([C:41]([F:44])([F:43])[F:42])[C:36]=2[Cl:45])[CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 69252183N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamineHCID 69253617N-(2-[2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine

Product 1

HCID 69254719n-(2-[3-Chlorophenyl]-propyl)-n(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamineYield 49%

Procedure

The titled compound was prepared from N-(2-Chloro-3-trifluoromethylbenzyl)-2-(2-chlorophenyl)propylamine in 49% yield in the same manner as the preparation of N-(2-[2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine in Example 184f. MS (ESI) 568 (MH+).

Sources & evidence

ORD record
ord-e9721861d6104e45bfa2f66188e6c69f
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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