N-(2-(2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine → N-(2-[3-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

HRID 902729Notes

Reaction equation

HRID 902729 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:38])[CH2:9][N:10]([CH2:23][CH2:24][CH2:25][O:26][C:27]2[CH2:28][C:29](=[CH:33][C:34]([O:36]C)=[O:35])[CH:30]=[CH:31][CH:32]=2)[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[C:13]=2[Cl:22])[CH:5]=[CH:6][CH:7]=1.ClC1C=CC=CC=1C(C)CN(CCCOC1CC(=CC(O)=O)C=CC=1)CC1C=CC=C(C(F)(F)F)C=1Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:38])[CH2:9][N:10]([CH2:23][CH2:24][CH2:25][O:26][C:27]2[CH2:28][C:29](=[CH:33][C:34]([OH:36])=[O:35])[CH:30]=[CH:31][CH:32]=2)[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:20])([F:19])[F:21])[C:13]=2[Cl:22])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 69251488N-(2-(2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamineHCID 69254719n-(2-[3-Chlorophenyl]-propyl)-n(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine

Product 1

HCID 131726847N-(2-[3-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochlorideYield 48%

Procedure

The titled compound was prepared from N-(2-[3-Chlorophenyl]-propyl)-N(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine in 48% yield in the same manner as the preparation of N-(2-[2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine in Example 184g. MS (ESI) 554 (MH+).

Sources & evidence

ORD record
ord-a49e3b6b63594deeb7f5650c31d8c8f5
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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