Propionic Acid → p-Methoxyphenylpropionic acid

HRID 902740Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.[C:13](O)(=O)CC>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])=[CH:7][CH:8]=1

Participants

Reactant 2

HCID 1032Propionic Acid

HCID 76904-Methoxyphenylacetic Acid

Product 1

HCID 257576p-Methoxyphenylpropionic acidYield 73%

Procedure

The titled compound was prepared from p-methoxyphenylacetic acid in 73% yield in the same manner as the preparation of 22-chlorophenyl)propionic acid in Example 184a. MS (ESI) 181 (MH+)

Sources & evidence

ORD record: ord-e2653636f6c7412b93eff68448f87d8d
Source dataset: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07365085B2

Reaction notes

Loading…