N-(2-(2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine → N-(2-[4-Methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

HRID 902743Notes

Reaction equation

HRID 902743 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([CH3:39])[CH2:10][N:11]([CH2:24][CH2:25][CH2:26][O:27][C:28]2[CH2:29][C:30](=[CH:34][C:35]([O:37]C)=[O:36])[CH:31]=[CH:32][CH:33]=2)[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[C:14]=2[Cl:23])=[CH:5][CH:4]=1.ClC1C=CC=CC=1C(C)CN(CCCOC1CC(=CC(O)=O)C=CC=1)CC1C=CC=C(C(F)(F)F)C=1Cl>>[ClH:23].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]([CH3:39])[CH2:10][N:11]([CH2:24][CH2:25][CH2:26][O:27][C:28]2[CH2:29][C:30](=[CH:34][C:35]([OH:37])=[O:36])[CH:31]=[CH:32][CH:33]=2)[CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:20])[F:21])[C:14]=2[Cl:23])=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 69251488N-(2-(2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamineHCID 69252286N-(2-[4-Methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine

Product 1

HCID 131726850N-(2-[4-Methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochlorideYield 66%

Procedure

The titled compound was prepared from N-(2-[4-methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine in 66% yield in the same manner as the preparation of N-(2-[2-Chlorophenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine in Example 184g. MS (ESI) 550 (MH+)

Sources & evidence

ORD record
ord-0d47b1e4a86041f88b1aa6da5bf36f8a
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

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