HRID902750

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)C=C1C=CC=C(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(C)c2ccc(OC)cc2)C1

HCID69252286

未命名化合物

结构：CC(C)CC(CNCc1cccc(C(F)(F)F)c1Cl)c1ccccc1

HCID69253156

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C=C1C=CC=C(OCCCN(Cc2cccc(C(F)(F)F)c2Cl)CC(CC(C)C)c2ccccc2)C1

HCID69252119

未命名化合物

收率 34%

PROCEDURE

实验过程

The titled compound was prepared from N-(2-chloro-3-trifluoromethylbenzyl)-2-phenyl-4-methylpentylamine in 34% yield in the same manner as the preparation of N-(2-[4-methoxyphenyl]-propyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carbomethoxymethylenephenoxy)propylamine in Example 188e. MS (ESI) 576 (MH+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-53fe0563b0b84785b629448391b5ea17
来源数据集: uspto-grants-2008_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07365085B2
来源说明: uspto-grants-2008_04

反应 SMILES

[Cl:1][C:2]1[C:21]([C:22]([F:25])([F:24])[F:23])=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][NH:5][CH2:6][CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:8][CH:9]([CH3:11])[CH3:10].COC1C=CC(C(C)CN([CH2:49][CH2:50][CH2:51][O:52][C:53]2[CH2:54][C:55](=[CH:59][C:60]([O:62][CH3:63])=[O:61])[CH:56]=[CH:57][CH:58]=2)CC2C=CC=C(C(F)(F)F)C=2Cl)=CC=1>>[C:12]1([CH:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[CH2:6][N:5]([CH2:49][CH2:50][CH2:51][O:52][C:53]2[CH2:54][C:55](=[CH:59][C:60]([O:62][CH3:63])=[O:61])[CH:56]=[CH:57][CH:58]=2)[CH2:4][C:3]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]([F:23])([F:24])[F:25])[C:2]=2[Cl:1])[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1