3-Methyl-2-phenylbutan-1-amine → N-(2-Phenyl-3-methylbutyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

HRID 902752Notes

Reaction equation

HRID 902752 reaction equation
[C:1]1(C(C(C)C)CN)[CH:6]=CC=C[CH:2]=1.Cl.[C:14]1([CH:20](CC(C)C)[CH2:21][N:22]([CH2:35][CH2:36][CH2:37][O:38][C:39]2[CH2:40][C:41](=[CH:45][C:46]([OH:48])=[O:47])[CH:42]=[CH:43][CH:44]=2)[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:33])([F:32])[F:31])[C:25]=2[Cl:34])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[ClH:34].[C:14]1([CH:20]([CH:1]([CH3:6])[CH3:2])[CH2:21][N:22]([CH2:35][CH2:36][CH2:37][O:38][C:39]2[CH2:40][C:41](=[CH:45][C:46]([OH:48])=[O:47])[CH:42]=[CH:43][CH:44]=2)[CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([C:30]([F:32])([F:33])[F:31])[C:25]=2[Cl:34])[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 98802173-Methyl-2-phenylbutan-1-amineHCID 131726851N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

Product 1

HCID 131726852N-(2-Phenyl-3-methylbutyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride

Procedure

The titled compound was prepared from 2-phenyl-3-methylbutylamine (Acta. Pharmaceutica Nordica (1992), 4(2), 105-9) in the same manner as the preparation of N-(2-Phenyl-4-methylpentyl)-N-(2-chloro-3-trifluoromethylbenzyl)-3-(3-carboxymethylenephenoxy)propylamine, hydrochloride, Example 189e-h. MS (ESI) 548 (MH+).

Sources & evidence

ORD record
ord-8cc11d307d4642eeaf79531d5d64818b
Source dataset
uspto-grants-2008_04
Patent number
US07365085B2

Reaction notes

Loading…