4-(Trifluoromethyl)benzoyl chloride → HCID 11215916, compound

HRID 902786Notes

Reaction equation

HRID 902786 reaction equation
[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12][NH2:13])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[S:19][CH:20]=[C:21]([C:23](Cl)=[O:24])[N:22]=1.[F:26][C:27]([F:38])([F:37])[C:28]1[CH:36]=[CH:35][C:31]([C:32](Cl)=[O:33])=[CH:30][CH:29]=1.[NH2:39][C:40]1[CH:52]=[CH:51][C:43]2[O:44]C(C)(C)[O:46][C:47](=[O:48])[C:42]=2[CH:41]=1>>[OH:44][C:43]1[CH:51]=[CH:52][C:40]([N:39]([CH2:17][C:18]2[S:19][CH:20]=[C:21]([C:23]([NH:13][CH2:12][C:11]3[CH:10]=[CH:9][C:8]([O:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:15][CH:14]=3)=[O:24])[N:22]=2)[C:32](=[O:33])[C:31]2[CH:35]=[CH:36][C:28]([C:27]([F:38])([F:37])[F:26])=[CH:29][CH:30]=2)=[CH:41][C:42]=1[C:47]([OH:48])=[O:46]

Participants

5

Reactant 4

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 2760343(4-Phenoxyphenyl)methanamineHCID 116153306-Amino-2,2-dimethyl-benzo[1,3]dioxin-4-oneHCID 597024562-(Chloromethyl)-1,3-thiazole-4-carbonyl chloride

Product 1

HCID 11215916HCID 11215916, compound

Procedure

The title compound was prepared following the procedure A using 4-phenoxybenzylamine, 2-(chloromethyl)-1,3-thiazole-4-carbonyl chloride, 4-(trifluoromethyl)benzoyl chloride and 6-amino-2,2-dimethyl-4H-1,3-benzodioxin-4-one. M+(ESI): 648.0

Sources & evidence

ORD record
ord-0625ee78321d45c1a020edda18a56b30
Source dataset
uspto-grants-2008_04
Patent number
US07365225B2

Reaction notes

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