4-(Trifluoromethyl)benzoyl chloride → HCID 11319685, compound

HRID 902793Notes

Reaction equation

HRID 902793 reaction equation
[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12][NH2:13])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1.[F:27][C:28]([F:39])([F:38])[C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1.[NH2:40][C:41]1[CH:53]=[CH:52][C:44]2[O:45]C(C)(C)[O:47][C:48](=[O:49])[C:43]=2[CH:42]=1>>[OH:45][C:44]1[CH:52]=[CH:53][C:41]([N:40]([CH2:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([NH:13][CH2:12][C:11]3[CH:10]=[CH:9][C:8]([O:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:15][CH:14]=3)=[O:23])=[CH:20][CH:19]=2)[C:33](=[O:34])[C:32]2[CH:36]=[CH:37][C:29]([C:28]([F:39])([F:38])[F:27])=[CH:30][CH:31]=2)=[CH:42][C:43]=1[C:48]([OH:49])=[O:47]

Participants

5

Reactant 4

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 701364-(Chloromethyl)benzoyl chlorideHCID 2760343(4-Phenoxyphenyl)methanamineHCID 116153306-Amino-2,2-dimethyl-benzo[1,3]dioxin-4-one

Product 1

HCID 11319685HCID 11319685, compound

Procedure

The title compound was prepared following the procedure A using 4-phenoxybenzylamine, 4-(chloromethyl)benzoyl chloride, 4-(trifluoromethyl)benzoyl chloride and 6-amino-2,2-dimethyl-4H-1,3-benzodioxin-4-one. M+(ESI): 641.0

Sources & evidence

ORD record
ord-59963e1307f6409fb5ec681cfd3a4de0
Source dataset
uspto-grants-2008_04
Patent number
US07365225B2

Reaction notes

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