Octylamine → 2-Hydroxy-5-{[{4-[(octylamino)carbonyl]benzyl}(phenoxyacetyl)amino]-methyl}benzoic acid

HRID 902795Notes

Reaction equation

HRID 902795 reaction equation
[CH2:1]([NH2:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl[CH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1.[O:21]([CH2:28][C:29](Cl)=[O:30])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.C(O)(=O)C.[NH2:36][CH2:37][C:38]1[CH:50]=[CH:49][C:41]2[O:42]C(C)(C)[O:44][C:45](=[O:46])[C:40]=2[CH:39]=1>>[OH:42][C:41]1[CH:49]=[CH:50][C:38]([CH2:37][N:36]([CH2:11][C:12]2[CH:20]=[CH:19][C:15]([C:16]([NH:9][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[O:17])=[CH:14][CH:13]=2)[C:29](=[O:30])[CH2:28][O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:39][C:40]=1[C:45]([OH:46])=[O:44]

Participants

5

Reactant 4

HCID 8143OctylamineHCID 69703Phenoxyacetyl chlorideHCID 701364-(Chloromethyl)benzoyl chlorideHCID 674204786-(aminomethyl)-2,2-dimethyl-4H-1,3-benzodioxin-4-one acetate

Product 1

HCID 113418012-Hydroxy-5-{[{4-[(octylamino)carbonyl]benzyl}(phenoxyacetyl)amino]-methyl}benzoic acid

Procedure

The title compound was prepared following the procedure A using octylamine, 4-(chloromethyl)benzoyl chloride, phenoxyacetyl chloride and 6-(aminomethyl)-2,2-dimethyl-4H-1,3-benzodioxin-4-one acetate. M+(ESI): 547.5

Sources & evidence

ORD record
ord-cdaf9ce7e31946e9be21d5107ae21098
Source dataset
uspto-grants-2008_04
Patent number
US07365225B2

Reaction notes

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