3-Cyclopentylpropionyl chloride → 5-{[(3-Cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)amino]methyl}-2-hydroxybenzoic acid

HRID 902798Notes

Reaction equation

HRID 902798 reaction equation
[CH2:1]([C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH2:11])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].Cl[CH2:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1.[CH:25]1([CH2:30][CH2:31][C:32](Cl)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26]1.C(O)(=O)C.[NH2:39][CH2:40][C:41]1[CH:53]=[CH:52][C:44]2[O:45]C(C)(C)[O:47][C:48](=[O:49])[C:43]=2[CH:42]=1>>[CH:25]1([CH2:30][CH2:31][C:32]([N:39]([CH2:40][C:41]2[CH:53]=[CH:52][C:44]([OH:45])=[C:43]([CH:42]=2)[C:48]([OH:49])=[O:47])[CH2:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([NH:11][CH2:10][C:9]3[CH:12]=[CH:13][C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:7][CH:8]=3)=[O:21])=[CH:18][CH:17]=2)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

5

Reactant 4

HCID 660393-Cyclopentylpropionyl chlorideHCID 701364-(Chloromethyl)benzoyl chlorideHCID 2775785(4-Pentylphenyl)methanamineHCID 674204786-(aminomethyl)-2,2-dimethyl-4H-1,3-benzodioxin-4-one acetate

Product 1

HCID 112270555-{[(3-Cyclopentylpropanoyl)(4-{[(4-pentylbenzyl)amino]carbonyl}benzyl)amino]methyl}-2-hydroxybenzoic acid

Procedure

The title compound was prepared following the procedure A using 4-pentylbenzylamine, 4-(chloromethyl)benzoyl chloride, 3-cyclopentylpropanoyl chloride and 6-(aminomethyl)-2,2-dimethyl-4H-1,3-benzodioxin-4-one acetate. M+(ESI): 585.5

Sources & evidence

ORD record
ord-c787cbafe96b4699b7586bd4f83ed489
Source dataset
uspto-grants-2008_04
Patent number
US07365225B2

Reaction notes

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