4-(Trifluoromethyl)benzoyl chloride → [4-({(4-{[(4-Phenoxybenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)benzoyl]amino}methyl) phenoxy]acetic acid

HRID 902804Notes

Reaction equation

HRID 902804 reaction equation
[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12][NH2:13])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1.[F:27][C:28]([F:39])([F:38])[C:29]1[CH:37]=[CH:36][C:32]([C:33](Cl)=[O:34])=[CH:31][CH:30]=1.C[O:41][C:42](=[O:53])[CH2:43][O:44][C:45]1[CH:50]=[CH:49][C:48]([CH2:51][NH2:52])=[CH:47][CH:46]=1>>[O:1]([C:8]1[CH:9]=[CH:10][C:11]([CH2:12][NH:13][C:22]([C:21]2[CH:25]=[CH:26][C:18]([CH2:17][N:52]([CH2:51][C:48]3[CH:49]=[CH:50][C:45]([O:44][CH2:43][C:42]([OH:53])=[O:41])=[CH:46][CH:47]=3)[C:33](=[O:34])[C:32]3[CH:36]=[CH:37][C:29]([C:28]([F:39])([F:38])[F:27])=[CH:30][CH:31]=3)=[CH:19][CH:20]=2)=[O:23])=[CH:14][CH:15]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 4

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 701364-(Chloromethyl)benzoyl chlorideHCID 2760343(4-Phenoxyphenyl)methanamineHCID 16770770Methyl [4-(aminomethyl)phenoxy]acetate

Product 1

HCID 58693695[4-({(4-{[(4-Phenoxybenzyl)amino]carbonyl}benzyl)[4-(trifluoromethyl)benzoyl]amino}methyl) phenoxy]acetic acid

Procedure

The title compound was prepared following the procedure A using 4-phenoxybenzylamine, 4-(chloromethyl)benzoyl chloride, 4-(trifluoromethyl)benzoyl chloride and methyl[4-(aminomethyl)phenoxy]acetate, acetate salt. M+(ESI): 669.2

Sources & evidence

ORD record
ord-0226fc86bff64b21bc35abff786073b1
Source dataset
uspto-grants-2008_04
Patent number
US07365225B2

Reaction notes

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