3-Cyclopentylpropionyl chloride → 4-[(3-Cyclopentylpropanoyl)(4-({(4-pentylbenzyl)amino]carbonyl}-benzyl)amino]-2-hydroxybenzoic acid

HRID 902806Notes

Reaction equation

HRID 902806 reaction equation
[CH2:1]([C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH2:11])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].Cl[CH2:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][CH:17]=1.[CH:25]1([CH2:30][CH2:31][C:32](Cl)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26]1.[NH2:35][C:36]1[CH:37]=[CH:38][C:39]2[C:44](=[O:45])[O:43]C(C)(C)[O:41][C:40]=2[CH:48]=1>>[CH:25]1([CH2:30][CH2:31][C:32]([N:35]([CH2:15][C:16]2[CH:24]=[CH:23][C:19]([C:20]([NH:11][CH2:10][C:9]3[CH:12]=[CH:13][C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:7][CH:8]=3)=[O:21])=[CH:18][CH:17]=2)[C:36]2[CH:37]=[CH:38][C:39]([C:44]([OH:45])=[O:43])=[C:40]([OH:41])[CH:48]=2)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

5

Reactant 4

HCID 660393-Cyclopentylpropionyl chlorideHCID 701364-(Chloromethyl)benzoyl chlorideHCID 2775785(4-Pentylphenyl)methanamineHCID 231100727-Amino-2,2-dimethyl-4H-1,3-benzodioxine-4-one

Product 1

HCID 586936824-[(3-Cyclopentylpropanoyl)(4-({(4-pentylbenzyl)amino]carbonyl}-benzyl)amino]-2-hydroxybenzoic acid

Procedure

The title compound was prepared following the procedure A using 4-pentylbenzylamine, 4-(chloromethyl)benzoyl chloride, 3-cyclopentylpropanoyl chloride and 7-amino-2,2-dimethyl-4H-1,3-benzodioxin-4-one. M+(ESI): 571.3

Sources & evidence

ORD record
ord-ec3eb89d57a8453f810067ea30314eee
Source dataset
uspto-grants-2008_04
Patent number
US07365225B2

Reaction notes

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