4-(Trifluoromethyl)benzoyl chloride → HCID 11204959, compound

HRID 902821Notes

Reaction equation

HRID 902821 reaction equation
[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH2:12][NH2:13])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:17][C:18]1[N:19]=[C:20]([C:23]2[CH:31]=[CH:30][C:26]([C:27](Cl)=[O:28])=[CH:25][CH:24]=2)[S:21][CH:22]=1.[F:32][C:33]([F:44])([F:43])[C:34]1[CH:42]=[CH:41][C:37]([C:38](Cl)=[O:39])=[CH:36][CH:35]=1.C[O:46][C:47](=[O:58])[CH2:48][O:49][C:50]1[CH:55]=[CH:54][C:53]([CH2:56][NH2:57])=[CH:52][CH:51]=1>>[O:1]([C:8]1[CH:9]=[CH:10][C:11]([CH2:12][NH:13][C:27]([C:26]2[CH:30]=[CH:31][C:23]([C:20]3[S:21][CH:22]=[C:18]([CH2:17][N:57]([CH2:56][C:53]4[CH:54]=[CH:55][C:50]([O:49][CH2:48][C:47]([OH:58])=[O:46])=[CH:51][CH:52]=4)[C:38](=[O:39])[C:37]4[CH:41]=[CH:42][C:34]([C:33]([F:44])([F:43])[F:32])=[CH:35][CH:36]=4)[N:19]=3)=[CH:24][CH:25]=2)=[O:28])=[CH:14][CH:15]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 4

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 2760343(4-Phenoxyphenyl)methanamineHCID 16770770Methyl [4-(aminomethyl)phenoxy]acetateHCID 586936994-[4-(Chloromethyl)-1,3-thiazol-2-yl]benzoyl chloride

Product 1

HCID 11204959HCID 11204959, compound

Procedure

The title compound was prepared following the procedure A using 4-phenoxybenzylamine, 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoyl chloride, 4-(trifluoromethyl)benzoyl chloride and methyl[4-(aminomethyl)phenoxy]acetate, acetate salt. M+(ESI): 752.9

Sources & evidence

ORD record
ord-478a3872047547e5a39e65e98ecf3846
Source dataset
uspto-grants-2008_04
Patent number
US07365225B2

Reaction notes

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