反应详情

Sodium methoxide (1.21 g) was added to a solution of methyl 2-(bromomethyl)acrylate (1.0 ml) in methanol (10 ml), and the mixture was heated under reflux for 26 hours. After cooling, the reaction mixture was diluted with diethyl ether, and precipitate was collected by filtration and the filtrate was concentrated under reduced pressure. The resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4) to obtain the title compound (726 mg).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 26 hours
3. temperatureAfter cooling
4. filtrationwas collected by filtration
5. concentrationthe filtrate was concentrated under reduced pressure
6. customThe resultant residue was purified by column chromatography on silica gel (ethyl acetate:hexane=1:4)