Potassium Hydroxide → HCID 85967320, compound

Participants

Reaction Steps

To the tri-ester of example 21 (38 g, 0.14 mol) in ethanol (456 mL) was added 77.6 mL of a 10% aqueous solution of potassium hydroxide. The resulting mixture was refluxed for 3 hours. The isolated product was purified by flash chromatography (SiO2, 90% dichloromethane-10% methanol) to afford 20.68 g (60.6% yield) of the title compound: 1H NMR (CDCl3, 400 MHz) 4.16 (q, 2H), 3.72 (t, 1H), 2.80 (d, 2H), 1.35 (s, 9H), 1.20 (t, 3H); 13C NMR (CDCl3, 400 MHz) 170.0, 168.9, 81.6, 62.4, 47.7, 34.5, 28.2, 14.5.

Provenance & Evidence