HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-tert-Butyl 2-amino-3-(tert-butoxy)propanoate → n-[1-(1-Carboxy-2-hydroxy-ethylcarbamoyl)-2-(1h-indol-3-yl)-ethyl]-3-(2-mercapto-3-phenyl-propionylamino)-succinamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-tert-Butyl 2-amino-3-(tert-butoxy)propanoate | HCID 6993439 | — |
| Reactant | 3-{2-[3-tert-Butoxycarbonyl-2-(3-phenyl-2-tritylsulfanyl-propionylamino)-propionylamino]-2-carboxyethyl}-indole-1-carboxylic acid tert-butyl ester | HCID 69211510 | — |
| Product | n-[1-(1-Carboxy-2-hydroxy-ethylcarbamoyl)-2-(1h-indol-3-yl)-ethyl]-3-(2-mercapto-3-phenyl-propionylamino)-succinamic acid | HCID 10370796 | — |
Reaction Steps
The title compound was prepared by condensing H-Ser(But)OBut with the protected dipeptide of Example 88, followed by deprotection and purification by HPLC (40%): (Pos. FAB)? (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07365091B2 |
| Source dataset | uspto-grants-2008_04 |
| ORD ID | ord-f165487bde974d958fd241ed25bb9de2 |
| Source note | uspto-grants-2008_04 |