HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine → HCID 23337277, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 1,2,4-Thiadiazole, 5-chloro-3-(trichloromethyl)- | HCID 79930 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 23337277 | HCID 23337277 | — |
Reaction Steps
To 14.2 grams (0.2 mole) pyrrolidine in 100 milliliters ether was added 23.8 grams (0.1 mole) 3-trichloromethyl-5-chloro-1,2,4-thiadiazole in 100 milliliters ether. The solution was refluxed with stirring for one hour after addition. Filtration to remove salt by-products yielded a clear filtrate which was concentrated on a steam bath to give 16.4 grams (60% molar yield) of white solid. Recrystallization from ligroin yielded a pure product (melting point 105.5°-107° C.). The structure was confirmed via infrared and elemental analysis. Analysis for C7H8N3Cl3S:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226609 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-4e7f432a75e4400c9d8e9ecf3130a98c |
| Source note | uspto-grants-1980_10 |