反应详情

温度

15 °C

50.0 g of 2-chloro-4-nitrophenyl isocyanate was added, with stirring, to 100 g of 2-chloroethanol. After 2 minutes, the temperature of the mixture rose to 65° C. The mixture then was heated at 80°-90° C. for 10 minutes, and cooled. 200 ml of ether and 200 ml of hexane were added, the mixture was cooled to 15° C. and filtered. Drying of the filter cake gave 2-chloroethyl (2-chloro-4-nitrophenyl)carbamate (1A), as a white solid, mp: 128°-130° C.

1. customrose to 65° C
2. temperatureThe mixture then was heated at 80°-90° C. for 10 minutes
3. temperaturecooled
4. filtrationfiltered
5. customDrying of the filter cake