反应详情

A solution of 11.25 g of sodium methoxide in 50 ml of methanol was added drop-by-drop to a stirred solution of 58.0 g of 1A in 400 ml of ethanol. The mixture was refluxed for 5 minutes, then the volatile materials were evaporated under reduced pressure. The residue was treated with water and extracted with ether. The extract was dried and concentrated under reduced pressure. The residue was cooled and filtered to give 3-(2-chloro-4-nitrophenyl)-2-oxazolidinone (1B), as a white solid, mp: 94°-96° C.

1. temperatureThe mixture was refluxed for 5 minutes
2. customthe volatile materials were evaporated under reduced pressure
3. additionThe residue was treated with water
4. extractionextracted with ether
5. customThe extract was dried
6. concentrationconcentrated under reduced pressure
7. temperatureThe residue was cooled
8. filtrationfiltered