Hydrogen Bromide → HCID 88778359, compound

Participants

Reaction Steps

Ethyl N-carbobenzoxy-N-(diisopropylthiophosphinylmethyl)glycine (2 g., 0.0044 mole) was reacted with 36% hydrogen bromide (8 ml) in glacial acetic acid. Ether was added and the oily precipitate was isolated by decanting the ether layer. The oil was washed with ether twice, then suspended in benzene and treated with propylene oxide. The solution was concentrated in vacuo to yield ethyl N-(diisopropylthiophosphinylmethyl)glycine (0.7 g., 0.0022 mole) as an oil, ND22 =1.5066.

Provenance & Evidence