Hydrogen Bromide → HCID 88776574, compound

Participants

Reaction Steps

Ethyl N-carbobenzoxy-N-(diisobutylthiophosphinylmethyl)glycine (4 g., 0.009 mole) was dissolved in 10 ml. of 35% hydrogen bromide in glacial acetic acid at 0° C. The mixture was stirred for one hour. Ether was added and the oily precipitate isolated by decanting the ether layer. The oil was washed twice with diethyl ether and then suspended in benzene and treated with propylene oxide. The solution was concentrated in vacuo to yield ethyl N-(diisobutylthiophosphinylmethyl)glycine (0.3 g., 0.001 mole) as an oil, ND25 =1.5121.

Provenance & Evidence