HCID 13046999, compound → 8-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine

HRID 903022Notes

Reaction equation

HRID 903022 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH2:12][N+:13]([O-])=[CH:14][CH:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:6]=2[CH:23]=1.CC(C)([O-])C.[K+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[CH:12]=[N:13][CH:14]=[C:10]3[CH2:9][N:8]=[C:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[F:22])[C:6]=2[CH:23]=1

Participants

4

Reactant 2

HCID 13046999HCID 13046999, compoundHCID 23665647Potassium tert-butoxide

Product 1

HCID 1859468-Chloro-6-(2-fluorophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 50 mg of 8-chloro-6-(2-fluorophenyl)-3a,4-dihydro-1H-imidazo[1,5-a][1,4]benzodiazepine 2-oxide in 3 ml of methanol containing 25 mg of potassium t-butoxide was heated to reflux for 10 min. The mixture was evaporated partially and the residue was partitioned between methylene chloride and sodium bicarbonate solution. The organic phase was dried and evaporated. Crystallization of the residue from ether yielded product with mp 148°-151° C.

Workup

  1. temperatureto reflux for 10 min
  2. customThe mixture was evaporated partially
  3. customthe residue was partitioned between methylene chloride and sodium bicarbonate solution
  4. customThe organic phase was dried
  5. customevaporated
  6. customCrystallization of the residue from ether yielded product with mp 148°-151° C.

Sources & evidence

ORD record
ord-f42494c252e143eebe4233b4fc817262
Source dataset
uspto-grants-1980_10
Patent number
US04226771

Reaction notes

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