反应详情

N(1,3-Dimethyl-5-pyrazolyl)-5-methyl isothiourea hydroiodide (Example XXV) (20.0 g) and 11.5 g. -N-methyl ethylenediamine were heated to 120° for 30 minutes and to 160° for 1 hour. After cooling, methylene chloride was added and the solid which formed was filtered and discarded. The methylene chloride solution was shaken with 15% KOH solution, dried over potassium carbonate, concentrated and the residue crystallized from acetonitrile to get 10.16 g. product, mp. 128°-130°.

1. temperatureAfter cooling
2. customthe solid which formed
3. filtrationwas filtered
4. dry with materialdried over potassium carbonate
5. concentrationconcentrated
6. customthe residue crystallized from acetonitrile
7. customto get 10.16 g