反应详情

A mixture of 4.2 g (0.01 mole) of 7-chloro-5-(2-fluorophenyl)-2,3-dihydro-N-hydroxy-α-(4-morpholinyl)-1H-1,4-benzodiazepine-2-methanimine 4-oxide, 50 ml of glacial acetic acid and 4 ml of acetaldehyde was heated to reflux for 5 minutes. The cooled reaction mixture was poured on ice, made alkaline with ammonia and extracted with methylene chloride. The extracts were dried and evaporated and the residue was crystallized from ether/2-propanol to yield yellow crystals.

1. temperaturewas heated
2. temperatureto reflux for 5 minutes
3. customThe cooled reaction mixture
4. additionwas poured on ice
5. extractionextracted with methylene chloride
6. customThe extracts were dried
7. customevaporated
8. customthe residue was crystallized from ether/2-propanol
9. customto yield yellow crystals