HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 20283993, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Carbon Tetrachloride | HCID 5943 | — |
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 3-Methyl-2-[4-(trifluoromethyl)anilino]butanenitrile | HCID 13457885 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 20283993 | HCID 20283993 | — |
Reaction Steps
To a solution of 484 mg (2 mmol) of 3-methyl-2-(4-trifluoromethylphenylamino)butyronitrile (III; R is hydrogen) in 5 ml. of carbon tetrachloride is added 267 mg. (2 mmol) of N-chlorosuccinimide. The mixture is heated at 65°. After about 48 hours, the mixture is poured into water and ether. The organic fraction is separated, washed with water, and brine, dried over sodium sulfate, and solvent removed to give 3-methyl-2-(2-chloro-4-trifluoromethylphenylamino)butyronitrile (III; R is chloro).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226802 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-97366a324abd43a2b5edd838f972b107 |
| Source note | uspto-grants-1980_10 |