反应详情

温度

140 °C

A mixture of 1,12-dodecanediol (10.2 g, 0.051 mol), sodium hydroxide (4.6 g, 0.11 mol), 120 ml of dimethyl sulfoxide, 20 ml of benzene and 6 ml of water was stirred at reflux under a nitrogen atmosphere for 12 hours. The water was azeotroped from the mixture with a Dean-Stark trap. After cooling, 17.5 g (0.11 mol) of 4-nitrophthalonitrile was added to the disodium salt of 1,12-dodecanediol prepared above. The resulting mixture was slowly heated to 140° C. and stirred at this temperature for 8 hours. The cooled reaction mixture was poured into 400 ml of cold water. The aqueous solution was extracted with three, 75 ml portions of methylene chloride. The combined extract was washed with water, charcoaled, and dried over anhydrous sodium sulfate and concentrated at reduced pressure. Recrystallization from ethanol-water yielded 10.1 g (45%) of 1,12-bis(3,4-dicyanophenoxy) dodecane.

1. temperatureat reflux under a nitrogen atmosphere for 12 hours
2. customThe water was azeotroped from the mixture with a Dean-Stark trap
3. temperatureAfter cooling
4. customprepared above
5. stirringstirred at this temperature for 8 hours
6. customThe cooled reaction mixture
7. extractionThe aqueous solution was extracted with three, 75 ml portions of methylene chloride
8. extractionThe combined extract
9. washwas washed with water
10. dry with materialdried over anhydrous sodium sulfate
11. concentrationconcentrated at reduced pressure
12. customRecrystallization from ethanol-water