反应详情

The oxalic acid salt of 3-(4-trifluoromethylphenoxy) azetidine (13.0 g., 0.042 mole) was partitioned between 50 ml. of benzene and 50 ml. of potassium hydroxide solution. The benzene layer was dried over calcium sulfate and filtered, and to the stirring dried benzene solution was added 2.6 g. (0.046 mole) of methyl-isocyanate. Stirring was continued overnight. The mixture was concentrated at reduced pressure and the solid residue was recrystallized from a mixture of isopropyl ether-ethyl acetate. The product weighed 7.5 g. (65%) and melted at 154°-157° C.

1. dry with materialThe benzene layer was dried over calcium sulfate
2. filtrationfiltered
3. additionto the stirring dried benzene solution was added 2.6 g
4. concentrationThe mixture was concentrated at reduced pressure
5. customthe solid residue was recrystallized from a mixture of isopropyl ether-ethyl acetate