HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → Fluzinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 3-[3-(Trifluoromethyl)phenoxy]azetidine | HCID 11138538 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | Fluzinamide | HCID 53467 | — |
Reaction Steps
To 6.0 g. (0.024 mole) of 3-(3-trifluoromethylphenoxy) azetidine in 50 ml. of dry benzene was added dropwise 1.37 g. (0.024 mole) of methylisocyanate with stirring, and stirring was continued for 30 minutes. The solid which crystallized in the flask was recrystallized using 95% ethanol to give 5.0 g. (76%) of product (m.p. 145°-147° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226861 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-868b300370dd4c3f90fca1ffe2ead79d |
| Source note | uspto-grants-1980_10 |