HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-6-chloro-1,3-benzenedisulfonamide → 4'-(2-Methylaminopropyl)-6-chlorospiro[2H-1,2,4-benzothiadiazine-3(4H),1'-cyclohexane]-7-sulfonamide-1,1-dioxide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-6-chloro-1,3-benzenedisulfonamide | HCID 67136 | — |
| Reactant | 4-(2-Methylaminopropyl) cyclohexanone | HCID 53781844 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4'-(2-Methylaminopropyl)-6-chlorospiro[2H-1,2,4-benzothiadiazine-3(4H),1'-cyclohexane]-7-sulfonamide-1,1-dioxide hydrochloride | HCID 23337798 | — |
Reaction Steps
A mixture of 4-(2-methylaminopropyl) cyclohexanone (4.0 g., 0.024 mole) and 4-amino-6-chloro-1,3-benzenedisulfonamide (4.4 g., 0.0154 mole) in 2 N ethanolic HCl (75 ml.) is refluxed for one hour and cooled to give 7.0 g. of 4'-(2-methylaminopropyl)-6-chlorospiro[2H-1,2,4-benzothiadiazine-3(4H)-1'-cyclohexane]-7-sulfonamide-1,1-dioxide hydrochloride which melts at 296° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04226867 |
| Source dataset | uspto-grants-1980_10 |
| ORD ID | ord-6c3fd071d4714af1be49aa23e12dfad8 |
| Source note | uspto-grants-1980_10 |