Methyl isothiocyanate → HCID 12919007, compound

Participants

Reaction Steps

A solution of methyl isothiocyanate (1.46 g; 0.20 mole) in chloroform (10 ml) was added dropwise during 10 minutes, to a stirred solution of 2-(2,3-dimethylphenoxymethyl)-2-imidazoline (4.08 g; 0.020 moles) prepared as in Example 1--in chloroform (50 ml) cooling to keep the reaction below 5° C. The reaction mixture was then allowed to warm to room temperature and finally refluxed for 5 hours. Chloroform was then evaporated in vacuo and the residue recrystallised from isopropanol to yield white crystals of 2-(2,3-dimethylphenoxymethyl)-1-N-methylthiocarbamoyl-2-imidazoline, m.p. ca 100° C. with decomposition.

Provenance & Evidence