6-Phenoxy-2-pyridinemethanol → N-(4-methylphenyl)valine

HRID 903167Notes

Reaction equation

HRID 903167 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]([CH:13]([CH3:15])[CH3:14])[C:11](=[O:16])[O:10]C2=O)=[CH:4][CH:3]=1.O(C1N=C(CO)C=CC=1)C1C=CC=CC=1>>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C@H:12]([C:11]([OH:16])=[O:10])[CH:13]([CH3:15])[CH3:14])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 128791556-Phenoxy-2-pyridinemethanolHCID 202892893-(4-Methylphenyl)-4-isopropyloxazolidine-2,5-dione

Product 1

HCID 53646739N-(4-methylphenyl)valine

Procedure

Following the above procedure, 3-(4-methylphenyl)-4-isopropyloxazolidine-2,5-dione is reacted with (6-phenoxy-2-pyridyl)methanol to give the (6-phenoxy-2-pyridyl)methyl ester of N-(4-methylphenyl)valine.

Sources & evidence

ORD record
ord-753f34b68098423cb8f424752bd1d449
Source dataset
uspto-grants-1980_10
Patent number
US04226872

Reaction notes

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